대한구강악안면방사선학회

Korean Academy of Oral and Maxillofacial Radiology

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Co-60조사가 백서 발치창 치유과정에 미치는 영향에 관한 실험적 연구
저자 : 유영준, 안형규
1982년|12권 1호|Page : 105-113|조회수 415
Full Text : 1982_105.pdf (1.2M)
TI : An experimental study of the effect of Co-60 irradiation on the healing process of extraction wounds in white rats

 AU : You YJ; Ahn HK
 AD : Dept. of Dental Radiology, Graduate School, Seoul National University
 SO : JKAMFR. 1982;12(1):105-113
 ISSN : 1225-049X
 LA : KOREAN
 CP : KOREA

 AB : Because of the development of rampant caries, osteomyelitis and osteoradionecrosis that occur after radiation therapy of oral cancers, extraction of teeth at or near the malignant lesion has been done in the past. Few, however, have studied the radiation effect on the healing of extraction wounds. The study is concerned with the effect of Co-60 irradiation on the healing process of extraction wounds in rats.
 Fifty six, male, Sprague-Dawley rats are used. The right first molar of the mandible is extracted from all animals. They are divided into three experimental groups of 14 each and a control group of 14. There experimental groups are irradiated respectively with 200 rad, 400 rad and 600 rad and a pair of rats in each group are killed on days 1, 3, 5, 7, 14, 21 and 28 after irradiation. Two animals from the control group are killed on the day when the experimental rats are killed. The irradiated hemimandibles are fixed in 10% neutral formalin, decalcified in 5% trichloroacetic acid, embedded in paraffin and sectioned. The sections are stained in hematoxylin and eosin, van Gison, Masson's trichrome or silver nitrate.
 Results show that in general radiation effects on healing extraction wounds are dose dependent; i.e., the higher is the dose, the greater is the histologic changes observed:
 1. Irradiation tends to retard blood clot organization and epithelial regeneration.
 2. An increase in th number of giant cells and osteoclasts is noted after irradiation.
 3. Formation of regenerating connective tissues around and within the extraction site is compromised, and a clear reduction of primitive mesenchymal type connective cells is noted.
 4. The healing process begins along the lateral aspect of the extraction socket in the control, while irregular histologic appearances of the trabecular pattern is present in the experimental rats.

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