대한구강악안면방사선학회

Korean Academy of Oral and Maxillofacial Radiology

학회지

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방사선조사가 악하선세포내 분비과립의 미세구조에 미치는 영향에 관한 실험적 연구
저자 : 최미, 이강숙, 최갑식
1994년|24권 2호|Page : 403-412|조회수 929
Full Text : 1994_403.pdf (924.7K)
TI : An experimental study of the radiation-induced changes on the secretory granules of the rat submandibular gland acinar cell

 AU : Choi M; Lee KS; Choi KS
 AD : Department of Dental Radiology, College of Dentistry, Kyungpook National University
 SO : JKAOMFR, 1994;24(2):403-412
 ISSN : 1225-049X
 PY : 1994
 LA : KOREAN
 CP : KOREA

 AB : The purpose of this study was to investigate the irradiation effects on the secretory granules of the rat submandibular gland acinar cell. For this study, Sprague-Dawley strain rats were irradiated to their neck region with the dose of 5Gy and 10Gy by 6MV X-radiation, and sacrificed on the experimental periods after irradiation. The authors observed the ultrastructural changes of the secretory granules of the rat submandibular gland acinar cell under a transmission electron microscope. The results were as follows: In the transmission electron microscopic examination, secretory granules were blurred in limiting membrane on the 3hours groups after irradiation. And they showed decrease in number, irregularities in shape and distributional pattern, and inhomogeneous internal electron density on the 1day and 3days groups. After then, these changes were recovered in shape and distributional pattern on the 14days groups, and changes of internal electron density and limiting membrane were recovered on the 28days groups after irradiation. Among the intracellular organelles, rough endoplasmic reticulum was scattered, but Golgi complex was not changed. And such pathologic changes were earlier and more prominent in 10Gy irradiated groups than in 5Gy irradiated groups.

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